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Aniara Grant

2008 Coagulation Grant Winner

Aniara is happy to announce the winner of the 2008 Aniara grant in the amount of $5000.

Graciela Krikun, PhD
Graciela Krikun, PhD
Dept. Ob/Gyn & Rep. Endo.
Director: Unit of Endometrial angiogenesis and hemostasis
Yale University, SOM
New Haven, CT. USA

Endometriosis is a major women’s health problem, characterized by the presence of endometrial tissue outside the uterine cavity causing pelvic adhesions, focal bleeding, infertility and pain. Its diagnosis is exceedingly difficult as symptoms are non-specific and definitive diagnoses require laparoscopy. Irrespective of etiology, long-term survival of endometriotic implants is associated with marked angiogenesis. In certain malignant and inflammatory states, tissue factor (TF) induces a potent pro-angiogenic milieu. We have previously shown that eutopic endometria from women with endometriosis display increased endometrial glandular epithelial cell TF expression. Moreover, endometriotic implants display aberrant expression of TF in endothelial cells and intense expression in macrophages. By contrast, in healthy women, TF levels are highest in the stromal cells of eutopic endometrium with minimal expression in epithelial cells. In the circulation, TF is associated with microvesicles. Inflammation results in increased shedding of microvesicles into the circulation. The central hypothesis of this proposal is that growth and angiogenesis of ectopic endometriotic tissue is associated with enhanced TF expression in endometrial epithelial, stromal and endothelial cells as well as leukocytes resulting in excessive shedding of TF-containing microvesicles into the circulation. Hence, we propose to study a cohort of women with and without endometriosis to establish if this disease can be detectable without the need for surgery.

In summary we will collect blood and intraperitoneal fluid and test for total microparticle expression in controls vs. patients. We will assess the percent of TF-expressing microparticles and will try to identify the cellular source of the microparticles. These studies represent bench-to-bedside translational research and have the potential to result in non-invasive methods of detection as well as the ability to follow progression of the disease.


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2010 - Leonardo Brandao, MD


2009 - Dr. Mirta Schattner, Ph.D.
2008 - Dr. Graciela Krikun, Ph.D.
2007 - Dr. Margaret Prechel, Ph.D.
2006 - Dr. A. Valance Washington, Ph.D

Scientific Advisiors

Dr. Dorothy Adcock
Medical Director/Laboratory Director Colorado Coagulation Consultants, Inc, dba Esoterix Coagulation Denver, Colorado

Dr. Kenneth A. Bauer
Professor of Medicine, Harvard Medical School. His hospital positions include Chief, Hematology Section, VA Boston Healthcare System, and Director, Thrombosis Clinical Research, Beth Israel Deaconess Medical Center.

Dr. Charles S. Eby
Associate Director of Educational Programs, Division of Laboratory Medicine at Washington University Saint Louis, Member of Barnes-Jewish Hospital Credentialing and Health Information Management Committees.

Dr. Andreas Hillarp
Position as hospital chemist at the Department of Clinical Chemistry, University Hospital, Malmö, Sweden.

Dr. Mervyn A. Sahud, M.D., A.B.I. M.-Hem.
Medical Director Coagulation Department Quest Diagnostics Nichols Institute

Dr. Sam Schulman
Associate professor in Internal Medicine at Karolinska Institute and since September 2004 also professor in medicine at McMaster University.

Agneta Siegbahn, MD, Ph.D.
Professor in Clinical Coagulation Science Department of Medical Sciences, Clinical Chemistry Akademiska Hospital, Uppsala, Sweden

Jogin R. Wu, Ph.D.
Associate Clinical Professor of Pathology, Duke University Medical Center. Associate Director, Clinical Coagulation Laboratory, Duke University Health System.

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